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Step by Step Describe the Consequences of P53 Gene Mutation

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When this gene would be transcribed the nucleotide sequence of mRNA would also be changed. In most cases the p53 gene is mutated giving rise to a stable mutant protein whose accumulation is regarded as a hallmark of cancer cells. Primary Information Of P53 Gene The tumor suppressor gene p53 has been identified as the most frequent target of genetic alterations in human cancers. . The more defective the mutation the greater the risk. This altered p53 protein cannot regulate cell growth and division and is unable to trigger apoptosis in cells with mutated or damaged DNA. Most of these mutations occur in highly conserved regions in the DNA-binding core domain of the p53 protein suggesting that the amino acid residues in these regions are critical for maintaining normal p53 structure and function. Describe starting from transcription to translation to activation ending with function how this protein s shape and function could ...
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